| dim. 31/10/2021 | 12e journée | ||
| 21h00 | Real Sociedad A. Isak 58′, sp | 1-1 | Athletic Bilbao Muniain 90′ |
| 18h30 | Getafe Enes Ünal 31′ Enes Ünal 56′ | 2-1 | Esp. Barcelone Sergi Gómez 38′ |
| 16h15 | Atl. Madrid Y. F. Carrasco 26′ G. A. Pezzella 63′, csc João Félix 80′ | 3-0 | Betis Séville |
| 14h00 | Cadix Á. Negredo 90′, sp | 1-1 | Real Majorque I. B. Mohammed 29′ |
| sam. 30/10/2021 | 12e journée | ||
| 21h00 | FC Barcelone Memphis Depay 49′ | 1-1 | Alaves Luis Rioja 52′ |
| 18h30 | FC Valence Hugo Guillamón 43′ Carlos Soler 77′, sp | 2-0 | Villarreal |
| 16h15 | FC Seville Diego Carlos 40′ Lucas Ocampos 60′ | 2-0 | Osasuna |
| 14h00 | Elche Pere Milla 86′ | 1-2 | Real Madrid V. Júnior 22′ V. Júnior 73′ |
| P | Equipe | Pts | J | G | N | P | Bp | Bc | Diff |
| 1 | Real Sociedad | 25 | 12 | 7 | 4 | 1 | 17 | 10 | +7 |
| 2 | Real Madrid | 24 | 11 | 7 | 3 | 1 | 26 | 12 | +14 |
| 3 | FC Seville | 24 | 11 | 7 | 3 | 1 | 19 | 7 | +12 |
| 4 | Atl. Madrid | 22 | 11 | 6 | 4 | 1 | 18 | 10 | +8 |
| 5 | Betis Séville | 21 | 12 | 6 | 3 | 3 | 19 | 15 | +4 |
| 6 | Osasuna | 19 | 12 | 5 | 4 | 3 | 14 | 15 | -1 |
| 7 | Rayo Vallecano | 19 | 11 | 6 | 1 | 4 | 18 | 12 | +6 |
| 8 | Athletic Bilbao | 18 | 11 | 4 | 6 | 1 | 11 | 7 | +4 |
| 9 | FC Barcelone | 16 | 11 | 4 | 4 | 3 | 16 | 12 | +4 |
| 10 | FC Valence | 16 | 12 | 4 | 4 | 4 | 18 | 17 | +1 |
| 11 | Real Majorque | 14 | 12 | 3 | 5 | 4 | 11 | 17 | -6 |
| 12 | Esp. Barcelone | 14 | 12 | 3 | 5 | 4 | 12 | 13 | -1 |
| 13 | Villarreal | 12 | 11 | 2 | 6 | 3 | 13 | 12 | +1 |
| 14 | Alaves | 10 | 11 | 3 | 1 | 7 | 6 | 14 | -8 |
| 15 | Elche | 10 | 12 | 2 | 4 | 6 | 9 | 15 | -6 |
| 16 | Celta Vigo | 10 | 11 | 3 | 1 | 7 | 10 | 14 | -4 |
| 17 | Cadix | 9 | 12 | 1 | 6 | 5 | 11 | 19 | -8 |
| 18 | Grenade | 8 | 10 | 1 | 5 | 4 | 8 | 14 | -6 |
| 19 | Levante | 6 | 11 | 0 | 6 | 5 | 11 | 20 | -9 |
| 20 | Getafe | 6 | 12 | 1 | 3 | 8 | 6 | 18 | -12 |
| Mis à jour le dimanche 31/10/2021 à 22h55 après Real Sociedad-Athletic Bilbao |