- Vendredi 29 octobre 2021
- Samedi 30 octobre 2021
- Dimanche 31 octobre 2021
Classement
| P | Equipe | Pts | J | G | N | P | Bp | Bc | Diff |
| 1 | RU St Gilloise | 28 | 13 | 9 | 1 | 3 | 29 | 13 | +16 |
| 2 | FC Bruges | 26 | 13 | 7 | 5 | 1 | 23 | 15 | +8 |
| 3 | Royal Antwerp | 24 | 13 | 7 | 3 | 3 | 23 | 16 | +7 |
| 4 | Charleroi SC | 23 | 13 | 6 | 5 | 2 | 25 | 14 | +11 |
| 5 | FC Malines | 23 | 13 | 7 | 2 | 4 | 25 | 23 | +2 |
| 6 | Anderlecht | 21 | 13 | 5 | 6 | 2 | 27 | 18 | +9 |
| 7 | Racing Genk | 20 | 13 | 6 | 2 | 5 | 27 | 22 | +5 |
| 8 | AS Eupen | 20 | 13 | 6 | 2 | 5 | 23 | 20 | +3 |
| 9 | KV Courtrai | 19 | 13 | 5 | 4 | 4 | 16 | 15 | +1 |
| 10 | La Gantoise | 17 | 13 | 5 | 2 | 6 | 21 | 15 | +6 |
| 11 | KV Oostende | 17 | 13 | 5 | 2 | 6 | 18 | 24 | -6 |
| 12 | Standard Liège | 16 | 13 | 4 | 4 | 5 | 14 | 21 | -7 |
| 13 | Saint-Trond | 15 | 13 | 4 | 3 | 6 | 14 | 20 | -6 |
| 14 | OH Louvain | 14 | 13 | 2 | 8 | 3 | 17 | 22 | -5 |
| 15 | Zulte-Waregem | 13 | 13 | 3 | 4 | 6 | 21 | 32 | -11 |
| 16 | RFC Seraing | 12 | 13 | 4 | 0 | 9 | 16 | 27 | -11 |
| 17 | Cercle Bruges | 9 | 13 | 2 | 3 | 8 | 13 | 20 | -7 |
| 18 | Beerschot Wil. | 5 | 13 | 1 | 2 | 10 | 12 | 27 | -15 |